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┌tgefi­ gŠ­askjal: Lei­beiningar
Skjaln˙mer: RklÝn-513
┌tg.dags.: 01/25/2019
┌tgßfa: 3.0
2.02.03.02.01 DHEA

Samheiti: Dehydroepiandrosteron (ekki sama og DHEAS)

Hide details for Sřnataka, geymsla og sřnasending Sřnataka, geymsla og sřnasending
Ger­ sřnis : Sermi, EDTA-plasma e­a Heparin-plasma
Sřni teki­ Ý serum glas me­ rau­um tappa me­ geli (gul mi­ja) e­a ßn gels (sv÷rt mi­ja) e­a Ý glas me­ fjˇlublßum tappa ßn gels (sv÷rt mi­ja) e­a teki­ Ý glas me­ grŠnum tappa . Litakˇ­i samkvŠmt Greiner.

Skili­ ni­ur og floti­ sett Ý plastglas me­ skr˙fu­um tappa.

Magn: 1 mL
Geymsla sřnis: KŠlir.
Sřnasending: Hra­sending til ˙tlanda.
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MVZ Labor PD Dr. Volkmann und Kollegen GbR
Kriegsstrasse 99
76133 Karlsruhe

Tel:á 0721 85000-0
Fax: 0721 85000-199

www.laborvolkmann.de
E-Mail:
álabor@laborvolkmann.de
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http://www.laborvolkmann.de/analysenspektrum/HTML/index.html

dehydroepiandrosteron.pdfdehydroepiandrosteron.pdf


Frˇ­leikur:



Dehydroepiandrosterone (DHEA) is the principal human C-19 steroid. DHEA has very low androgenic potency, but serves as the major direct or indirect precursor for most sex steroids. DHEA is secreted by the adrenal gland and production is at least partly controlled by adrenocorticotropic hormone (ACTH). The bulk of DHEA is secreted as a 3-sulfoconjugate dehydroepiandrosterone sulfate (DHEAS). Both hormones are albumin bound, but DHEAS binding is much tighter. As a result, circulating concentrations of DHEAS are much higher (>100-fold) compared to DHEA. In most clinical situations, DHEA and DHEAS results can be used interchangeably. In gonads and several other tissues, most notably skin, steroid sulfatases can convert DHEAS back to DHEA, which can then be metabolized to stronger androgens and to estrogens.

Elevated DHEA/DHEAS levels can cause symptoms or signs of hyperandrogenism in women. Men are usually asymptomatic, but through peripheral conversion of androgens to estrogens can occasionally experience mild estrogen excess. Most mild-to-moderate elevations in DHEAS levels are idiopathic. However, pronounced elevations of DHEA/DHEAS may be indicative of androgen-producing adrenal tumors. In small children, congenital adrenal hyperplasia (CAH) due to 3 beta-hydroxysteroid dehydrogenase deficiency is associated with excessive DHEA/DHEAS production. Lesser elevations may be observed in 21-hydroxylase deficiency (the most common form of CAH) and 11 beta-hydroxylase deficiency. By contrast, steroidogenic acute regulatory protein (STAR) or 17 alpha-hydroxylase deficiency is characterized by low DHEA/DHEAS levels


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Ingibj÷rg Loftsdˇttir
Sigr˙n H PÚtursdˇttir
Gu­mundur Sig■ˇrsson
KristÝn Sigurgeirsdˇttir

Sam■ykkjendur

┴byrg­arma­ur

═sleifur Ëlafsson

┌tgefandi

Sigr˙n H PÚtursdˇttir

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