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Útgefiđ gćđaskjal: Leiđbeiningar
Skjalnúmer: Rklín-446
Útg.dags.: 01/24/2019
Útgáfa: 2.0
2.02.03.02.01 Carbamazepin-11-epoxid

Samheiti: 10,11-Epoxycarbamazepine, Carbamazepine epoxide; Carbamazepine 10,11-epoxide; 10,11-Epoxycarbamazepine; Carbamazepine 10,11-oxide;
Hide details for Sýnataka, geymsla og sýnasending Sýnataka, geymsla og sýnasending
Gerđ sýnis : Serum
Sýni tekiđ í serum glas međ rauđum tappa án gels (svört miđja) . Litakóđi samkvćmt Greiner.

Magn: 1 ml
Geymsla sýnis: Kćlir
Sýnasending: Hrađsending til útlanda
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MVZ Labor PD Dr. Volkmann und Kollegen GbR
Kriegsstrasse 99
76133 Karlsruhe

Tel:  0721 85000-0
Fax: 0721 85000-199

www.laborvolkmann.de
E-Mail:
 labor@laborvolkmann.de
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carbamazepin-10-11-epoxid.pdfcarbamazepin-10-11-epoxid.pdf

Carbamazepin-10, -11-Epoxid

MVZ Labor PD Dr. Volkmann und Kollegen GbR 1 04.05.2012

Präanalytik Blutentnahme am Ende eines Dosierungsintervalls
Material Serum, 1 mL
Therap. Bereich etwa 10 - 25 % des Carbamazepin-Spiegels
Methode HPLC
Qualitätskontrolle Zertifikat
Anforderungsschein Download und Analysenposition
Auskünfte Klinische Chemie und Toxikologie
Stoffgruppe Antiepileptika
Handelsnamen Carbamazepinepoxid

Fróđleikur:

Image result for carbamazepine-11-epoxide mechanism



Useful For: Monitoring patients exhibiting symptoms of carbamazepine toxicity whose serum carbamazepine concentration is within the therapeutic range, but who may be producing significant levels of the active metabolite epoxide

Carbamazepine is a common antiepileptic drug. It is a first-line drug for treatment of partial seizures and trigeminal neuralgia.

 Carbamazepine is metabolized by the liver to carbamazepine-10,11-epoxide (CBZ10-11) which is pharmacologically active and potentially toxic. CBZ10-11 is, in turn, inactivated by hepatic conversion to a transdiol derivative.

 CBZ10-11 may be responsible for the congenital abnormalities that are sometimes associated with the use of carbamazepine during early pregnancy. There have been cases of severe seizures exacerbation when serum epoxide levels were increased.

Toxic levels of CBZ10-11 can occur during:

1. Concomitant administration of other drugs that induce hepatic oxidizing enzymes (eg, most antiepileptic drugs [with the exception of valproic acid and the benzodiazepines], propoxyphene)

2. Concomitant administration of drugs that inhibit its breakdown such as valproic acid, felbamate, and lamotrigine

3. High-dose carbamazepine therapy, especially in combination with the above conditions


Ritstjórn

Ingibjörg Loftsdóttir
Sigrún H Pétursdóttir
Guđmundur Sigţórsson
Kristín Sigurgeirsdóttir

Samţykkjendur

Ábyrgđarmađur

Ísleifur Ólafsson

Útgefandi

Sigrún H Pétursdóttir

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