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Útgefiđ gćđaskjal: Leiđbeiningar
Skjalnúmer: Rklín-517
Útg.dags.: 09/25/2019
Útgáfa: 8.0
2.02.03.02.01 GUT-Hormón

Samheiti: Gastrin, Pancreatic Glucagon, VIP (Vasoactive Intestinal Polypeptide), Somatostatin, PP (Pancreatic Polypeptid), Neurotensin, Chromogranin B (GAWK fragment)
Hide details for Sýnataka, geymsla og sýnasending Sýnataka, geymsla og sýnasending
Sjúklingur verđur ađ hafa fastađ frá kl 22 kvöldiđ fyrir sýnatöku.

Lyfiđ Rantidine (Histamin 2 blokker) ćtti ekki ađ taka 72 klst fyrir blóđtöku. Lyfiđ Omerprazole ćtti ekki ađ taka 2 vikum fyrir blóđtöku.
Hypercalcemia og nýrnabilun getur valdiđ hćkkun á gildi gastríns

Gerđ sýnis : EDTA-plasma.

Sýni tekiđ í 2-4 ÍSKĆLD glös međ fjólubláum tappa án gels (svört miđja)
Sett strax í kćlikubb (ísvatn) og snúiđ STRAX niđur í kćldri skilvindu.



Magn:
4-8 mL plasma (mín 3ml). Plasma fryst 15 mín eftir blóđtökuna!

Geymsla sýnis: Frystir.
Sýnasending: Sent í ţurrís til útlanda.
Hide details for Pöntunarkóđi í FlexLabPöntunarkóđi í FlexLab
Kóđi: GUT

Beiđni: beiđni, Hammersmith, GUT.docbeiđni, Hammersmith, GUT.doc SAS_Request_Form.pdfSAS_Request_Form.pdf

Senda helst DHL trakk-slóđ til netfangs: paul.baec@.nhs.net
Hide details for Heiti tilvísunarannsóknastofu og heimilisfangHeiti tilvísunarannsóknastofu og heimilisfang

Hammersmith
Paul Bech
The SAS Laboratories
Clinical Biochemistry and Medical Oncology
Charing Cross Hospital

Fullham Palace Road
London W6 8RF
UK

paul.bec@nhs.net
Tel: 020 3311 1234

Spurningar um svör og rannsókn GUT-hormóna:

Email:

tricia.tan@nhs.net

w.dhillo@imperial.ac.uk

paul.bech@nhs.net

Tel: 020 3313 3949

Hide details for HeimildirHeimildir
Gut Hormones (Gastrin; Glucagon, VIP, PP)
Chemical Pathology
Notes

Gut hormone levels are indicated in the investigation of patients with symptoms suggestive of a neuroendocrine tumour or for screening of patients with multiple endocrine neoplasia type I

The profile includes the following gut hormones: 

    • Gastrin
    • Glucagon
    • Pancreatic polypeptide
    • Vasoactive intestinal polypeptide
    • Somatostatin
    • Chromogranin A and B
Neurotensin no longer forms part of the routine profile but is available in certain circumstances - please contact the Duty Biochemist if considered necessary.

CART (cocaine- and amphetamine related transcript) is also available if considered necessary - again please contact the duty biochemist.

 Sample requirements

    • Patients should fast overnight (10 hours).
    • Histamine 2 blockers such as ranitidine should be stopped for 72 hours and protein pump inhibitors such as omeprazole stopped two weeks before this test.
 For adults 2 x 4mL pre-chilled EDTA tubes on ICE

4mL EDTA tube

Storage/transport

 Do not store. Send immediately to the laboratory on ICE as the sample must be separated and plasma frozen within 15 minutes.

Required information

Relevant clinical details including current medication.

Turnaround times

The samples are sent frozen by courier on a weekly basis to the Hammersmith Hospital for analysis with results expected back within four weeks.

Reference ranges

  

Hormone
Reference Range
Units
Gastrin
<40
pmol/L
Glucagon
<50
pmol/L
PNCP (PP)

 (pancreatic polypeptide)

<300
pmol/L
VIP

(vasoactive intestinal polypeptide)

<30
pmol/L
Somatostatin
<150
pmol/L
CART

 (cocaine- and amphetamine-related transcript)

(available by special request only)

<85
pmol/L
Chromogranin A
<60
pmol/L
Chromogranin B
<150
pmol/L
Neurotensin

(available by special request only)

<100
pmol/L



https://pinboard.in/u:duty_biochemist/t:GutHormone/


Fróđleikur:

A gut hormone screen is used for the diagnosis of a variety of endocrine tumours of the pancreas, ganglioneuromas, gastrinomas or G-cell hyperplasia. Analysis includes gastrin, VIP, somatostatin, pancreatic polypeptide, and glucagon.

The gastrin test is usually requested to help detect high levels of gastrin and stomach acid. It is used to help diagnose gastrin-producing tumours called gastrinomas, Zollinger-Ellison (ZE) syndrome, and hyperplasia of G-cells, specialised cells in the stomach that produce gastrin. It may be measured to screen for the presence of multiple endocrine neoplasia type I (MEN) It may be used if a person has abdominal pain, diarrhoea, and recurrent peptic ulcers. A gastrin test may also be requested to look for recurrence of disease following surgical removal of a gastrinoma.

Vasoactive intestinal peptide (VIP) measurement is required for diagnosis of pancreatic tumour or a ganglioneuroma which secretes VIP. Administration of VIP to animals causes hyperglycaemia, inhibition of gastric acid, secretion of pancreatic bicarbonate and of small intestinal juice, and a lowering of systemic blood pressure with skin flush. These features are seen in patients with a tumour of this type which is secreting VIP.

Glucagon is measured for preoperative diagnosis of a glucagon-producing tumour of the pancreas in patients with diabetes and a characteristic skin rash (necrolytic migratory erythema).

Pancreatic polypeptide (PP) production is most commonly associated with tumours producing vasoactive intestinal polypeptide and with carcinoid syndrome and, less commonly, with insulinomas and gastrinomas.

When secreted by endocrine tumours, somatostatin appears to produce symptoms similar to those seen on pharmacological administration, i.e. steatorrhoea, diabetes mellitus and gall stones.


http://www.heftpathology.com/item/gut-hormones.html
https://www.nbt.nhs.uk/sites/default/files/Collection%20of%20Blood%20for%20Gastrin%20and%20Gut%20Hormones.pdf


Ritstjórn

Ingibjörg Loftsdóttir
Sigrún H Pétursdóttir
Guđmundur Sigţórsson
Kristín Sigurgeirsdóttir

Samţykkjendur

Ábyrgđarmađur

Ísleifur Ólafsson

Útgefandi

Sigrún H Pétursdóttir

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