SUPRA-REGIONAL ASSAY SERVICE (SAS) FOR PEPTIDE HORMONES
The Peptide Hormones laboratory is part of the Supra-Regional Assay Service (www.sas-centre.org). The laboratory specialises in the investigation of hypoglycaemia and offers tests for the diagnosis of most endocrine and some metabolic causes of low blood glucose, including insulin, C-peptide, proinsulin, beta-hydroxybutyrate, oral hypoglycaemic agents, IGF-I, IGF-II, IGFBP-3 and IGFBP-2. The laboratory has considerable experience in the investigation of factious hypoglycaemia and with the handling of chain of custody samples.
The laboratory also has an interest in the investigation of growth disorders and the clinical utility of IGFs and their binding proteins.
The laboratory also runs the UK NEQAS Guildford Peptide Hormones scheme which includes the analytes; insulin, C-peptide, gastrin, IGF-I and IGFBP-3 (www.ukneqas.org.uk).
CONSULTANTS AND SENIOR STAFF
Dr G Wark, Consultant Clinical Scientist, Director of the SAS Peptide Hormones service
Dr C Livingstone, Consultant Chemical Pathologist, Deputy Director of the service
Mrs A Armstrong, Senior Clinical Scientist
Mr N J Porter, Biomedical Scientist 2
TECHNICAL & CLINICAL QUERIES
Telephone Number: 01483 406715
Fax Number: 01483 464168
LABORATORY WORKING HOURS
MON, TUE, WED, THU, FRI - 0900 – 1730
SAT, SUN, Bank Holidays - No service
Information regarding specimen and transportation requirements can be found in the test directory at www.nhspathology.fph.nhs.uk and www.assayfinder.com
SAS REQUEST FORM can be downloaded here: SAS Request Form (Word Format) or SAS Request form (PDF Format)
Samples can be sent to the laboratory by Royal Mail, Hays Dx and by courier. Patient samples should be labelled with three points of identification. All fields on the request form must be completed in full with patient first and last name, date of birth, sex and hospital/NHS number, sample type, date and time, the assay requested as well as requesting hospital name and address and your accession number. Please also provide full clinical details and drug history
SAS Peptide Hormones Section
Clinical Laboratory, Level B
Royal Surrey County Hospital
Samples should be sent in packaging that is compliant with current postal regulations.
Insulin-like growth factor 2 (IGF-2) is one of three protein hormones that share structural similarity to insulin. The MeSH definition reads: "A well-characterized neutral peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like and mitogenic activities. The growth factor has a major, but not absolute, dependence on somatotropin. It is believed to be a major fetal growth factor in contrast to Insulin-like growth factor 1, which is a major growth factor in adults
It is sometimes produced in excess in islet cell tumors, causing hypoglycemia. Doege-Potter syndrome is a paraneoplastic syndrome in which hypoglycemia is associated with the presence of one or more non-islet fibrous tumors in the pleural cavity. Loss of imprinting of IGF2 is a common feature in tumors seen in Beckwith-Wiedemann syndrome. As IGF2 promotes development of fetal pancreatic beta cells, it is believed to be related to some forms of diabetes mellitus. Preeclampsia induces a decrease in methylation level at IGF2 demethylated region, and this might be among the mechanisms behind the association between intrauterine exposure to preeclampsia and high risk for metabolic diseases in the later life of the infants.[
|Insulin-like Growth Factor II (IGF-I|
Click here to magnify the image.
|Reference Range:||See biochemistry report|
|Turnaround Time:||1 week|
|Comments:||Also request IGF-1|
IGF-II: IGF-1 ratio is determined
|Description:||Insulin-like Growth Factor II (IGF-II)|
|Sample Requirements:||Minimum 0.3 mL|
Store frozen unless sent immediately