../ IS  
Útgefiđ gćđaskjal: Leiđbeiningar
Skjalnúmer: Rklín-170
Útg.dags.: 12/16/2020
Útgáfa: 4.0
2.02.03.02.01 Alzheimermarkerar

Samheiti: Alzheimermarkörer, CSV-beta-Amyloid, Csv-Tau, CSV-Fosfo-tau (Csv-Ptau), Alzheimer disease
Hide details for Sýnataka, geymsla og sýnasending Sýnataka, geymsla og sýnasending
Gerđ sýnis : Mćnuvökvi
Magn: 10 ml (min 1 ml) tekiđ í Polypropylen glas

Geymsla sýnis Frystir
Sýnasending: Hrađsending á ţurrís
Hide details for Heiti tilvísunarannsóknastofu og heimilisfangHeiti tilvísunarannsóknastofu og heimilisfang
Neurokemi Hus V3
Laboratoriemedicin/Klinisk kemi
Göteborgsvägen 31
431 80 Mölndal SE

Telefon: 031-343 00 25
FAX: 031-343 24 26
E-mail: neurokemi.su@vgregion.se
Hide details for HeimildirHeimildir

Ný viđmiđunargildi:
The new cut–offs is for individuals over 50 years and are as follows:

BiomarkerCut-off
tTau<409 ng/L
pTau<50 ng/L
Am42>620 ng/L
Am42/40 * 10>0.72

Tau protein.htmTau protein.htm Fosforylerat tau.htmFosforylerat tau.htmCsv-Amyloid beta 42.htmCsv-Amyloid beta 42.htm



Fróđleikur: Alzheimer's disease (AD) is the leading cause of dementia, affecting >35 million people worldwide . The neuropathologic hallmarks of AD are the neuritic plaques and neurofibrillary tangles, which, respectively, arise from the extracellular deposition of the amyloid-beta (Aβ) peptide and from the intracellular accumulation of hyperphosphorylated tau protein in neurons. The pathophysiological changes that cause cognitive, functional, and behavioral impairment in AD allegedly start several years or perhaps decades before the onset of clinical symptoms . Molecular and neuroimaging markers portray the presence of AD pathology therefore, AD biomarkers may play an important role in the diagnostic workup of patients with cognitive impairment, particularly among those with clinical symptoms compatible with prodromal AD



Image result for alzheimer

At the gross anatomical level, Alzheimer disease is characterized by brain atrophy associated with loss of synapses and neurons. At the microscopic level, deposition of extracellular amyloid-β plaques and intraneuronal neurofibrillary tangles is observed, in association with dystrophic neurites and loss of synapses, as well as microgliosis and astrogliosis



Viđmunargildi hjá Sahlgrenska:

Eining ng/L

beta-Amyloid (1-42)

Vuxna
Ĺldersintervall
Referensintervall
 
>=50 ĺr
>620

Tau
Barn
Ĺldersintervall
Referensintervall
 
<1 ĺr
Saknas
 
1 ĺr - <18 ĺr
<300

 

Vuxna
Ĺldersintervall
Referensintervall
 
18 ĺr - <50 ĺr
<360
 
>=50 ĺr
<479

Ptau
Vuxna
Ĺldersintervall
Referensintervall
 
>=50 ĺr
<61











Ritstjórn

Kristín Sigurgeirsdóttir
Sigrún H Pétursdóttir
Guđmundur Sigţórsson
Ingibjörg Loftsdóttir

Samţykkjendur

Ábyrgđarmađur

Ísleifur Ólafsson

Útgefandi

Sigrún H Pétursdóttir

Upp »


Skjal fyrst lesiđ ţann 12/13/2018 hefur veriđ lesiđ 390 sinnum