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┌tgefi­ gŠ­askjal: Lei­beiningar
Skjaln˙mer: RklÝn-500
┌tg.dags.: 01/23/2019
┌tgßfa: 3.0 CDT

Samheiti: Carbohydrate Deficient Transferrin, Desialotransferrin, finnst vi­ CDG – congenital disorders of glykolysation

Hide details for Sřnataka, geymsla og sřnasending Sřnataka, geymsla og sřnasending
Ger­ sřnis : Sermi.
Serum glas me­ rau­um tappa me­ geli (gul mi­ja). Litakˇ­i samkvŠmt Greiner.

Magn: 2 mL
Geymsla sřnis: KŠlir.
Sřnasending: Hra­sending Ý umhverfishita.
Hide details for Heiti tilvÝsunarannsˇknastofu og heimilisfangHeiti tilvÝsunarannsˇknastofu og heimilisfang
MVZ Labor PD Dr. Volkmann und Kollegen GbR
Kriegsstrasse 99
76133 Karlsruhe

Tel:á 0721 85000-0
Fax: 0721 85000-199

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Frˇ­leikur: Carbohydrate-deficient transferrin (CDT) is a biomarker for chronic alcohol intake of more than 60 g ethanol/d. It has been reported to be superior to conventional markers like gamma-glutamyltransferase (GGT) and mean corpuscular volume MCV). This review covers theoretical and analytical aspects, with data from controlled drinking experiments and from different population subgroups such as subjects with different liver diseases or different drinking patterns. CDT determinations are particularly indicated in (1) cases of chronic alcohol consumption and relapses after withdrawal,(2) license reapplication after driving under alcohol influence, (3) differentiating patients with enzyme-inducing medication from those with alcohol abuse, (4) congenital disorders of glycosylation such as carbohydrate-deficient glycoprotein syndrome Ia (CDGS Ia), and (5) patients treated for galactosemia. The main advantage of CDT is its high specificity, as evidenced in combination with increased alcohol consumption. CDT values are not markedly influenced by medication except in immunosuppressed patients, who may show low CDT values. In general, CDT values appear less elevated after alcohol intake in women. The main disadvantage is the relatively low sensitivity. Hence, this parameter is not suitable for screening for subjects with alcohol abuse in the general population. As CDT, GGT, and MCV are connected with chronic alcohol consumption by different pathophysiological mechanisms, a combination of these parameters will further improve the diagnostic value.


Ingibj÷rg Loftsdˇttir
Sigr˙n H PÚtursdˇttir
Gu­mundur Sig■ˇrsson
KristÝn Sigurgeirsdˇttir



═sleifur Ëlafsson


Sigr˙n H PÚtursdˇttir

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