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Skjaln˙mer: RklÝn-326
┌tg.dags.: 05/15/2018
┌tgßfa: 5.0
2.02.03.02.01 ACE Ý mŠnuv÷kva

Samheiti: Peptidyldipeptidase, Angiotensin converting enzyme, Angiotensin-1-Converting Enzym, Csv-ACE,
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Magn: 2 ml.

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MVZ Labor PD Dr. Volkmann und Kollegen GbR
Kriegsstrasse 99
76133 Karlsruhe

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angiotensin-1-converting-enzym.pdfangiotensin-1-converting-enzym.pdf

ACE vi­mi­unargildi fyrir mŠnuv÷kva er <2 U/L

Frˇ­leikur: Angiotensin-converting enzyme or ACE, is a central component of the renin-angiotensin system, which controls blood pressure by regulating the volume of fluids in the body. It converts the hormone angiotensin I to the active vasoconstrictor angiotensin II.

Recently , we questioned the clinical utility of
determining the level of angiotens in-converting enzyme (ACE) in
cerebrospinal fluid (CSF) for the diagno sis of neurosarcoidosis.
The diagnosis of sarcoidosis, a multisystem granulomatous disorder
of unknown etiology, is typically based on clinical signs and
symptoms supported by radiographic findings and the presence of
noncaseating epithelioid granulomas in more than one organ.
Elevated serum levels of ACE, hypercalciuria, and hypercalcemia
provide supportive, but not diagnostic, evidence of sarcoidosis .
Approximately 5% of patients with sarcoidosis have neurologic
involvement. When neurolog ic symptom s occur in the absence
of other organ system abnormalities, the diagnosis of neurosarco
idosis is especially problematic. Measurement of CSF
levels of ACE has been advocated as a means of distinguishing
between neurosarcoidosis and other nonsarcoid neurologic disease
Ěprocesses. Although several scientific publications have
supported the use of CSF ACE levels for the diagnosis of
neurosarcoidosis , many of them are letters to the editor with little
or no supporting data.!"


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