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Útgefiđ gćđaskjal: Leiđbeiningar
Skjalnúmer: Rklín-612
Útg.dags.: 10/11/2018
Útgáfa: 1.0
2.02.03.02.01 14-3-3 prótein

Samheiti: Creutzfeldt-Jakob,
Hide details for Sýnataka, geymsla og sýnasending Sýnataka, geymsla og sýnasending
Gerđ sýnis : Mćnuvökvi

Magn: 2 ml
Geymsla sýnis: Frystir
Sýnasending: Hrađsending á ţurrís
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MVZ Labor PD Dr. Volkmann und Kollegen GbR
Kriegsstrasse 99
76133 Karlsruhe

Tel:  0721 85000-0
Fax: 0721 85000-199

www.laborvolkmann.de
E-Mail:
 labor@laborvolkmann.de
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14-3-3-protein.pdf14-3-3-protein.pdf

Fróđleikur: Detectable 14-3-3 protein in the cerebrospinal fluid (CSF) is indicative of substantial, relatively rapid neuronal destruction. Increased CSF concentrations of 14-3-3 proteins have been described in patients with various forms of Creutzfeldt-Jakob disease (CJD), some other rapidly progressive dementias, and a large range of other vascular, inflammatory, neoplastic, and metabolic central nervous system (CNS) disorders , which can be associated with significant and rapid neuronal destruction. The most common forms of dementia (progressive multi-infarct dementia and Alzheimer disease) are uncommonly associated with elevated CSF levels of 14-3-3, presumably because of their slow pace of progression. Regardless of the method used, measurement of 14-3-3 protein in CSF should not be relied upon exclusively to establish the diagnosis of Creutzfeldt-Jakob disease (CJD). Increased concentrations of 14-3-3 protein in CSF have been described in a variety of central nervous system (CNS) diseases other than CJD that are associated with relative rapid (days to months, rather than months to years) destruction of significant amounts of CNS neuronal tissue

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Ingibjörg Loftsdóttir
Sigrún H Pétursdóttir
Guđmundur Sigţórsson
Kristín Sigurgeirsdóttir

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Ábyrgđarmađur

Ísleifur Ólafsson

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