Leptin.pdf

Fróðleikur: Leptin- When the leptin receptor sites are blocked by inflammatory chemicals produced in response to biotoxins, leptin levels increase and leptin resistance ensues.  The excess leptin causes weight gain and fat deposition, and increases appetite.  People with high leptin can gain weight on 1000 calories or less. Leptin, the "satiety hormone"^] is a hormone made by adipose cells that helps to regulate energy balance by inhibiting hunger. Leptin is opposed by the actions of the hormone ghrelin, the "hunger hormone". Both hormones act on receptors in the arcuate nucleus of the hypothalamus to regulate appetite to achieve energy homeostasis. In obesity, a decreased sensitivity to leptin occurs, resulting in an inability to detect satiety despite high energy stores.

When leptin increases as the result of a biotoxin exposure, there is a simultaneous decrease in alpha MSH secretion from the hypothalamus (alpha melanocyte stimulating hormone). When leptin increases and alpha MSH decreases simultaneously we can completely explain their clinical symptoms.