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Útgefið gæðaskjal: Leiðbeiningar
Skjalnúmer: Rklín-328
Útg.dags.: 06/02/2023
Útgáfa: 5.0
2.02.02.01 Procollagen-III-peptíð

Samheiti: Procollagen, PIIINP, Procollagen-3 N-Terminal Peptid, Prókollagen-3-peptíð,
Hide details for Sýnataka, geymsla og sýnasending Sýnataka, geymsla og sýnasending
Gerð sýnis : Sermi, EDTA-plasma eða heparín-plasma

Sýni tekið í serum glas með rauðum tappa með geli (gul miðja) eða í glas (inniheldur EDTA) með fjólubláum tappa án gels (svört miðja) eða í glas (inniheldur LiHeparin) með grænum tappa (svört miðja)
Litakóði samkvæmt Greiner

Magn: 1mL (hemólýsufrítt).

Geymsla sýnis: Kælir
Sýnasending: Hraðsending til útlanda
Hide details for Heiti tilvísunarannsóknastofu og heimilisfangHeiti tilvísunarannsóknastofu og heimilisfang
MVZ Labor PD Dr. Volkmann und Kollegen GbR
Kriegsstrasse 99
76133 Karlsruhe

Tel:  0721 85000-0
Fax: 0721 85000-199

www.laborvolkmann.de
E-Mail: labor@laborvolkmann.de
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prokollagen-3-peptid.pdfprokollagen-3-peptid.pdf

http://www.laborvolkmann.de/analysenspektrum/HTML/index.html

Fróðleikur:Monitoring for hepatic fibrosis, particularly in patients receiving methotrexate treatment who should be checked at three to six month intervals.Methotrexate is a successful form of treatment for psoriasis and rheumatoid arthritis (RA).  It has, however, been noted that prolonged exposure can result in irreversible hepatic fibrosis the risk of which is idiopathic but associated with cumulative doses of more than 1.5g (usually encountered in psoriasis as lower doses are used in RA). Previously it was advised that a liver biopsy be considered after each cumulative 1.5g methotrexate.  In 1996 it was shown that serum P3NP concentrations were predictive of the development of hepatic fibrosis. Continually raised P3NP concentrations were found to be associated with fibrosis in 78-100% of cases, but were only seen in 15-18% of subjects with a normal liver on biopsy. Current guidelines on the use of methotrexate in psoriasis suggest P3NP measurements be carried out annually and three monthly after a raised value.


www.laborvolkmann.de

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