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Útgefið gæðaskjal: Leiðbeiningar
Skjalnúmer: Rklín-328
Útg.dags.: 06/02/2023
Útgáfa: 5.0
2.02.02.01 Procollagen-III-peptíð
Samheiti: Procollagen, PIIINP, Procollagen-3 N-Terminal Peptid, Prókollagen-3-peptíð,
Sýnataka, geymsla og sýnasending
Sýnataka, geymsla og sýnasending
Gerð sýnis :
Sermi, EDTA-plasma eða heparín-plasma
Sýni tekið í serum glas með rauðum tappa
með geli (gul miðja)
eða í glas (inniheldur EDTA) með fjólubláum tappa
án gels (svört miðja)
eða í glas (inniheldur LiHeparin) með grænum tappa (svört miðja)
Litakóði samkvæmt Greiner
Magn:
1mL (hemólýsufrítt).
Geymsla sýnis:
Kælir
Sýnasending:
Hraðsending til útlanda
Pöntunarkóði í FlexLab
Pöntunarkóði í FlexLab
P3NP
Beiðni:
anforderungsschein_3a.pdf
Dálkur þrjú
Heiti tilvísunarannsóknastofu og heimilisfang
Heiti tilvísunarannsóknastofu og heimilisfang
MVZ Labor PD Dr. Volkmann und Kollegen GbR
Kriegsstrasse 99
76133 Karlsruhe
Tel: 0721 85000-0
Fax: 0721 85000-199
www.laborvolkmann.de
E-Mail:
labor@laborvolkmann.de
Heimildir
Heimildir
prokollagen-3-peptid.pdf
http://www.laborvolkmann.de/analysenspektrum/HTML/index.html
Fróðleikur:
Monitoring for hepatic fibrosis, particularly in patients receiving methotrexate treatment who should be checked at three to six month intervals.Methotrexate is a successful form of treatment for psoriasis and rheumatoid arthritis (RA). It has, however, been noted that prolonged exposure can result in irreversible hepatic fibrosis the risk of which is idiopathic but associated with cumulative doses of more than 1.5g (usually encountered in psoriasis as lower doses are used in RA). Previously it was advised that a liver biopsy be considered after each cumulative 1.5g methotrexate. In 1996 it was shown that serum P3NP concentrations were predictive of the development of hepatic fibrosis. Continually raised P3NP concentrations were found to be associated with fibrosis in 78-100% of cases, but were only seen in 15-18% of subjects with a normal liver on biopsy. Current guidelines on the use of methotrexate in psoriasis suggest P3NP measurements be carried out annually and three monthly after a raised value.
www.laborvolkmann.de
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