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┌tgefi­ gŠ­askjal: Lei­beiningar
Skjaln˙mer: RklÝn-531
┌tg.dags.: 02/25/2020
┌tgßfa: 4.0
2.02.03.02.01 ALL-NOPHO, Minimal Residual Disease Monitoring (MRD)

Samheiti: ß lÝka vi­ AML-NOPHO (diagnose T-ALL e­a AML) MRD Flow, ALL-NOPHO 2008, ALL2008 NOPHO MRD analyser,

Hide details for Sřnataka, geymsla og sřnasending Sřnataka, geymsla og sřnasending
Ger­ sřnis : Mergur og/e­a blˇ­ (stundum mŠnuv÷kvi)
Sřni teki­ Ý glas me­ fjˇlublßum tappa ßn gels (sv÷rt mi­ja) . Litakˇ­i samkvŠmt Greiner.


Magn: 10 ml ( Blˇ­ 5-10 ml, mergur 5 ml)
Geymsla sřnis: KŠlir / stofuhiti.
Sřnasending: Hra­sending til ˙tlanda.
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Klinisk immunologisk afd Kl

Afsnit VŠvstypelaboratoriet (VTL) 76-3-1
Tagensvej 20
2200 K°benhavn

Tlf: 3545 7631
Fax: 3539 8766​

Senda DHL slˇ­ ß ■etta netfang: rh-fp-mrd-leukemia@regionh.dk og segja Ý pˇsti hva­a mŠling er be­i­ um

Kontaktperson: 3545 6767 Ovl Hann Marquart

E-mail: 7631@regionh.dk,
rh-fp-webgruppen@regionh.top.local hanne.kristine.hegaard@regionh.dk

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Rekvirering:Sundhedsplatformen/Rekvisitionsseddel
Laboratorium:Rigshospitalet Blegdamsvej, Klinisk Immunologisk Afdeling, VŠvstypelaboratoriet 7631
Analysegruppe/Ansvarlig:VTL 76-3-1
Seneste gennemgang - Initialer : 29/10/2019 - TWT
IFCC-IUPAC-kode og navn:DNK35920 Marv—LeukŠmi-restsygdom; fr.(diagnostisk immungenrearrangement (mňlt med RQ-PCR)) = ?
Synonymer:MRD, MRD-PCR, PCR-MRD, Minimal restsygdom, Minimal restsygdomsmňling, Minimal Residual Disease.
Beskrivelse:Real time kvantitativ PCR, iht. guidelines for EUROMRD
Indikation:ALL patienter (herunder b°rn og voksne, der behandles efter NOPHO-protokol)
• T-ALL behandlingsmonitorering
• Infant ALL behandlingsmonitorering
• B-ALL behandlingsmonitorering, specielt ved dňrlig MRD-flow mark°r
Obs relaps (af ALL eller anden sygdom med kendt MRD-PCR mark°r)
Relapsmonitorering (incl. b°rn behandlet efter IntReALL2010 protokol)
NHL behandlingsmonitorering
CLL behandlingsmonitorering
MRD kontrol f°r SCT (af sygdom med kendt MRD-PCR mark°r)
MRD kontrol efter SCT (af sygdom med kendt MRD-PCR mark°r)
Akkrediteret analyse:DANAKááááá
MetodeopsŠtning:
CE-mŠrket analyseopsŠtning:
Mutationdetektionsprincip: Real time kvantitativ PCR, iht. guidelines for EUROMRD
Metrologisk sporbarhed:
Pr°vemateriale:Marv
Alternativt pr°vemateriale:
Pr°vetagningsr°r (Labka):1 stk Lilla9S. (K3-EDTA)
Pr°vemŠngde:5 ml.
Opbevaring:Pr°ven skal vŠre pň VŠvstypelaboratoriet hurtigst muligt og senest 24 timer efter pr°vetagning.
Mň sendes med r°rpost:Nej
Svartid:4-10 arbejdsdage.
Hastesvar: 3 dage.
Ekstern kvalitetskontrol:
Svartid:
Svarmuligheder:

Analyseusikkerhed: á
Henvisning:Kontakt VŠvstypelaboratoriet pň tlf. 3545 7631.
Gyldig fra:08/12/2015
Gyldig til:

20170126T092125.pdf20170126T092125.pdf 20170126T101004.pdf20170126T101004.pdf

Frˇ­leikur:
Minimal residual disease (MRD) is the name given to small numbers of leukaemic cells (cancer cells from the bone marrow) that remain in the patient during treatment, or after treatment when the patient is in remission (no symptoms or signs of disease). It is the major cause of relapse in cancer and leukemia. Up until a decade ago,[when?] none of the tests used to assess or detect cancer were sensitive enough to detect MRD. Now, however, very sensitive molecular biology tests are available, based on DNA, RNA or proteins. These can measure minute levels of cancer cells in tissue samples, sometimes as low as one cancer cell in a million normal cells.

In cancer treatment, particularly leukaemia, MRD testing has several important roles: determining whether treatment has eradicated the cancer or whether traces remain, comparing the efficacy of different treatments, monitoring patient remission status as well as detecting recurrence of the leukaemia or cancer, and choosing the treatment that will best meet those needs .

The tests are not simple, are often part of research or trials, and some have been accepted for routine clinical use.




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Ingibj÷rg Loftsdˇttir
Sigr˙n H PÚtursdˇttir
Gu­mundur Sig■ˇrsson
KristÝn Sigurgeirsdˇttir

Sam■ykkjendur

┴byrg­arma­ur

═sleifur Ëlafsson

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Sigr˙n H PÚtursdˇttir

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